Endocrine Abstracts

A 34-year-old lady with previous renal stones, constipation and well controlled bipolar mood disorder, on lithium for 13 years, was referred with a high calcium of 2.75 mmol/l (normal range: 2.10–2.58 mmol/l) and raised parathyroid hormone of 9.1 pmol/l (normal range: 1.1–4.2 pmol/l). Urine calcium excretion and TFT were normal.The biochemistry was consistent with primary hyperparathyroidism. A workup for possible underlying MEN syndrome came b...

Local regulation of T3 action in bone and cartilage is a novel mechanism underlying the pathogenesis of osteoarthritis (OA). Accelerated chondrocyte differentiation is a hallmark of OA and T3 regulates this process. The type 1 and 2 deiodinases (D1, D2) convert the pro-hormone T4 to the active hormone T3 whilst D3 inactivates both T3 and T4. D1 contributes to circulating T3 levels and local T3</s...

Pregnancy causes significant physiological changes that can alter the results of thyroid function testing. The changes in circulating plasma-binding protein (TBG) concentrations interfere with FT4 estimate methods, and the hCG thyrotropic effect impacts TSH activity estimation. A TSH assay is the most sensitive test to assess thyroid status. T4 levels have been implicated as associated with fetal neurodevelopment. During pregnancy, differences in FT4 concentrations have been d...

Articular cartilage maintenance and repair is regulated by numerous endocrine and paracrine factors. Investigation of molecular mechanisms underlying osteoarthritis (OA) is limited by inability to identify early stage disease and individuals at risk of progression. Susceptibility to OA is genetically determined and the availability of mice from the International Knockout Mouse Consortium with deletions of every known gene provides a unique opportunity to investigate its pathop...

Procalcitonin (PCT) is a peptide precursor of the hormone calcitonin. Procalcitonin is synthesized by a large number of tissues and organs in response to invasion by pathogenic bacteria, fungi and some parasites. Its a new and innovative parameter which reacts with high sensitivity and specificity to generalized infection and sepsis.Objective: The aim of the study was to assess PCT value for the diagnosis of systemic infection.Meth...

Differentiated thyroid cancer (DTC) is more frequent in women than in men.The aim of the study was to analyze whether factors connected with the female sex could increase the risk of DTC.Material and methods: Ninety nine patients with a mean age±S.D. of 40.5±5.9 years with DTC and 51 healthy women with a mean age of 36.52±8.3 years were examined. Gynecological and obstetric histories were taken and ser...

Objective: To determine the predictive risk factors for the development of type 2 diabetes mellitus (DM) in patients with impaired glucose tolerance (IGT) or impaired fasting glucose (IFG) during the 8.5 follow up.Research design and methods: This is an 8-year prospective study in a randomly selected urban population including 2838 subjects aged ≥40 years living in Krakow. Seven hundred and six had IGT (387) or IFG (319) based on WHO criteria and 2...

Bone loss in anorexia nervosa and following bariatric surgery is associated with an elevated circulating concentration of the gastrointestinal anorexigenic hormone peptide YY (PYY), which acts principally via the Y1R and Y2R receptors. Selective deletion of Y1R in osteoblasts or Y2R in the hypothalamus results in high bone mass, but deletion of PYY has resulted in conflicting skeletal phenotypes leading to uncertainty regarding its role in the regulation of bone mass. We hypot...

Mice with dominant-negative mutations of thyroid hormone receptor α1 (TRα1) are euthyroid but display growth retardation and delayed bone age as juveniles and increased bone mass during adulthood, indicating impaired skeletal thyroid hormone responsiveness. The first autosomal dominant mutations affecting TRα1 in humans were recently described in two unrelated children and one parent who were euthyroid apart from a low T4:T3 ratio. Consiste...

Background: Type 3 neuroendocrine tumors of the stomach (type 3 NETV) are very rare subtypes of NETV with poor prognosis, not fully understood biology and not well investigated diagnostic and therapeutic procedures. The aim of the study was to analyze tumor biology and the outcome of differentiated treatment in patients with type 3 neuroendocrine tumors of the stomach.Methods: A prospective 10 years follow up of five patients with type 3 NETV treated in ...